Abstract

MONTERO GONZALEZ, Teresita; HURTADO DE MENDOZA AMAT, José; CABREJAS ACUNAS, Ofelia María  and  ALMARALES ACOSTA, María Rosa. Histopatología del daño múltiple de órganos en un modelo experimental de ratón quemado. Rev Cub Med Mil [online]. 2002, vol.31, n.1, pp. 13-22. ISSN 1561-3046.

The multiple organ failure syndrome is a "systemic inflammatory response" caused by the action of multiple mediators that lead to the progressive dysfunction of organs and systems. The multiple organ failure is known as the morphological alterations of the dead with this diagnosis. The disease due to burns presents all the pathogenic bases to develop both processes (clinical and morphological). That’s why it was decided to characterize the hystopathology in an experimental model of burned mouse. Female balbc/c mice of 20 ± 2 g, depilated and anaesthetized, were used according to the ethical standards established to work with laboratory animals. The paravertebral dry burn was obtained with an automatic welder adapted with 100 ºC of temperature and during 20". The vitality and morphology were compared between the control group (n=5) and the burned (n=24) that were applied euthanasia (n=6) at 24 h, 72 h, 7 days and 14 days. The t test was used to compare percentages and the G test to analyze the dependence among variables. It was observed that in the burned animals there was a dependency (G=64.04**; (p < 0.01) among the injuries with degrees from mild to moderate (the individuals who died spontaneously were excluded) and the multiple organ failure was moderate in all the burned mice. These data confirm that the multiple organ failure is an almost compulsory alteration of the disease produced by burn that may lead to death owing to the functional organ failure (multiple organ dysfunction syndrome), which justifies the efforts made to prevent or attenuate the systemic inflammatory response that supports it.

Keywords : MULTIPLE ORGAN FAILURE [pathology]; MICE, INBRED BALB C; ANIMALS, LABORATORY; BURNS [pathology]; AUTOPSY; MILITARY MEDICINE.

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