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Revista Cubana de Medicina Militar

Print version ISSN 0138-6557On-line version ISSN 1561-3046


NODARSE HERNANDEZ, Rafael; BRANA SUAREZ, Juan Carlos  and  PALACIOS ALFONSO, Irene. Determination of bactericidal power of 0.5 % vancomycin cream related to Staphylococcus aureus strains used in burn patients. Rev Cub Med Mil [online]. 2009, vol.38, n.3-4. ISSN 0138-6557.

OBJECTIVE. To determine the bactericidal power per se of the 0.5 % Vancomicyn cream (0.2 % Nitrofurazone cream as vehicle) to guarantee its use in topical treatment of infections caused by Staphylococcus aureus in burned patients. METHODS. We used 0,5 % Vancomicyn cream obtained adding two bulbs of hydrochlorate (500 mg) to a cream small bottle of 0.2 % Nitrofurazone (200 mg).To determine its bactericidal power in vitro a susceptibility test to antimicrobials by disk-diffusion method. Disk used were prepared to that effect embedded in Vancomicyn cream plus Nitrofurazone to achieve the desired concentration. We used 7 strains corresponding to Staphylococcus aureus isolated from patients (wild strains) to be exposed to study disks. RESULTS. One, two and three strains corresponded to Methicillin-sensitive staphylococcus, where as the four, five, six and seven strains were resistant to this antibiotic. CONSLUSIONS. The 0.5 % Vancomicyn cream was able to inhibits the in vitro growth of wild strains of S. aureus causing the infections, of Methicillin-sensitive strains and those resistant to this antibiotic. This effect was achieved per se and not by Nitrofurazone synergism, which was ineffective in face of Methicillin-resistant S. aureus.

Keywords : Staphylococcus aureus; Vancomicyn; sensitivity test.

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