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Revista Cubana de Medicina Militar

Print version ISSN 0138-6557


GONZALEZ GUIBERT, María Luisa et al. Adverse reactions to drugs in a surgical emergency unit. Rev Cub Med Mil [online]. 2014, vol.43, n.2, pp.216-227. ISSN 0138-6557.

Introduction: adverse drug reactions in surgical units constitute a health problem little known, so there is little research concerning this topic. Objective: to characterize adverse drug reactions in patients operated on at the Surgical Emergency Unit of "Dr. Luis Díaz Soto" Central Military Hospital. Methods: a prospective, observational study was conducted using active and passive methods of Drug Safety. The sample consisted of 2128 patients operated in 2010.These patients were monitored daily through a counseling list of syndromes for adverse reactions and by health professional reports. Results: out of the patients operated on, 65 (3.05 %) had at least one adverse drug reaction with a rate of occurrence of 1.12 %. Most reports were in patients aged 45-59 years (40.0 %) and female (69.2 %). the highest rate of reporting was contributed by general anesthetics and antimicrobial (36.9 % and 18.5 % respectively); cefazolin and ketamine were the most reported drugs with 13.8 %. Skin was the most affected organ system and skin rash was the most common clinical manifestation (17.8 %). Moderate adverse reactions occurred more frequently. Conclusions: the importance of pharmacovigilance is highlighted, especially in sensitive areas such as surgical units, where adverse drug reactions are common.

Keywords : adverse drug reactions; ADRs; operating room; vigilance; pharmacovigilance.

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