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Revista Cubana de Medicina Militar

Print version ISSN 0138-6557On-line version ISSN 1561-3046


VILCHEZ CACEDA, Héctor Alexander; INOCENTE CAMONES, Miguel Angel  and  FLORES LOPEZ, Oscar Bernuy. Healing activity of six hydroalcoholic extracts of plants in incised wounds of Rattus norvegicus albinus. Rev Cub Med Mil [online]. 2020, vol.49, n.1, e489.  Epub Mar 01, 2020. ISSN 0138-6557.


In military medicine, natural healing agents against incision wounds are relevant in the treatment of the military.


To evaluate the healing activity of the hydroalcoholic extracts of Peperomia congona Sodiro (congona), Annona muricata L. (guanabana), Urtica urens L. (ortiga), Ormosia coccinea (Aubl) Jacks (huairuro), Opuntia ficus-indica L. Mill. (tuna) and Musa acuminata Colla (platano bellaco) in incised wounds of Rattus norvegicus albinus (albino rat).


Experimental analytical study of prospective and longitudinal type. The preliminary phytochemical analysis of the 6 extracts was carried out. We used 80 male albino rats, randomized and distributed in 8 groups (n = 10). A dermal application was made during 10 consecutive days after the generation of incised wounds that were made on the back. Group I (0.9% sodium chloride). Group II (commercial healing gel). From Group III to VIII they were treated with hydroalcoholic extract of congona, guanábana, ortiga, huairuro, tuna and platano bellaco respectively. The evolution of healing was followed on days 1, 5 and 11 and measured in millimeters.


The presence of alkaloids, phenolic compounds and flavonoids was detected in the 6 extracts; in addition to coumarins in congona, tannins in guanábana, nettle, tuna and huayruro, quinonas in guanábana and plantain bellaco. The healing activity was verified in the extracts of guanabana (69.77 %), tuna (66.27 %), platano bellaco (64.38 %), ortiga (56.73 %), congona (55.74 %) and huayruro (54.50 %), compared with a commercial gel (72.21 %).


The hydroalcoholic extract of the leaves of Annona muricata L. (guanábana) showed the highest healing activity in incised wounds of male albino rats.

Keywords : wounds; scar activity; Peperomia congona Sodiro; Annona muricata L.; Urtica urens L.; Ormosia coccinea (Aubl) Jacks; Opuntia ficus-indica (L.) Mill.; Musa acuminata colla.

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