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Revista Cubana de Medicina Militar
On-line version ISSN 1561-3046
Abstract
VERA-PONCE, Víctor Juan; TALAVERA, Jesús Enrique; TORRES-MALCA, Jenny Raquel and DE LA CRUZ-VARGAS, Jhony A.. Combinations of metabolic syndrome and risk of diabetes mellitus. Rev Cub Med Mil [online]. 2022, vol.51, n.1 Epub Mar 01, 2022. ISSN 1561-3046.
Introduction:
Metabolic syndrome is associated with an increased risk of diabetes, so its clinical identification helps to identify these patients at high risk.
Objective:
To determine the combinations of metabolic syndrome for the risk of type 2 diabetes mellitus in a sample of Peruvian population.
Methods:
5-year cohort study of secondary analysis of the PERU MIGRANT study database. The altered components of the metabolic syndrome were low high-density lipoprotein, hypertriglyceridemia; and elevated glucose, blood pressure and waist circumference. In total 35 subgroups of metabolic syndrome components: 5 groups for each of the 5 components, 10 groups for combinations of 2 components and 3 components, 5 groups for the combination of 4 components.
Results:
In the multiple regression analysis, only G as an independent factor presented a statistically significant relative risk (RR= 9.02; 95 % CI 2.45 - 33.24; p= 0.001). In relation to the combination of 2 factors, only the combination of glucose-elevated abdominal waist (RR= 7.28; 95 % CI 1.21 - 43.64; p= 0.030) and glucose-high-density lipoprotein (RR= 10.94; 95 % CI 2.71 - 44.23; p= 0.001) presented a statistically significant relative risk. Finally, patients with the glucose-high-density lipoprotein-abdominal waist combination had 7.80 times the risk of presenting type 2 diabetes mellitus versus those who did not (PR= 7.80; CI: 95 % 1.39 - 43.77; p= 0.020).
Conclusion:
The combinations that include at the same time glucose - high density lipoproteins - abdominal waist, were the most associated combinations.
Keywords : metabolic syndrome; diabetes mellitus; blood glucose; HDL lipoproteins; waist circumference.