Abstract

MAS LAGO, PEDRO et al. Mecanismo de participación de los Enterovirus en la neuropatía epidémica.: Hipótesis fisiopatológicas. Rev Cubana Med Trop [online]. 1997, vol.49, n.3, pp. 186-195. ISSN 1561-3054.

During the epidemic neuropathy occurred in Cuba from 1992 to 1993, viral isolations antigenically connected with Coxsackie viruses were obtained from the cerebrospinal fluid of patients. Virological, epidemiological, toxicologic, nutritional, immunological and histopathological investigations were made. Though the disease was related to toxic and nutritional factors, it has been impossible to identify the cause of the epidemic. Taking into consideration the results of the different investigations, we have formulated a comprehensive and multifactorial hypothesis to explain the physiopathological mechanism of the participation of the isolated viruses as mediators in a process of autoimmunity of the pathogeny of the disease.

Keywords : NEURITIS [virology]; NEURITIS [etiology]; NEURITIS [physiopatology]; ENTEROVIRUSES [immunology]; ENTEROVIRUSES [genetics]; ENTEROVIRUSES [isolation & purification]; RNA, VIRAL; ANTIGENS, VIRAL; IMMUNE SYSTEM; VIRAL PROTEIN; GENES VIRAL; COXSACKIE- VIRUSES [isolation & purification]; COXSACKIEVIRUSES [immunology]; COXSACKIEVIRUSES [genetics]; CUBA.