Abstract

DIAZ GONZALEZ, MANUEL et al. Reacciones adversas y respuesta inmune de la vacuna Heberbiovac-HB aplicada a lactantes, simultáneamente con la DPT y la VA-MENGOC-BC. Rev Cubana Med Trop [online]. 1997, vol.49, n.3, pp. 196-203. ISSN 1561-3054.

The Cuban recombinant yeast-derived hepatitis B vaccine (Heberbiovac-HB) was administered to 2 groups of infants aged 3 months. A dosage of 10 mg was used through a scheme of 0, 1 and 6 and 0, 1, 2 and 12, coinciding with the DPT and antimeningococcical vaccines, according to the immunization schedule. Reactogenecity and immunogenecity were studied in both groups. The reactions observed were mild and similar to other studies, where febricula, erythema and induration were the most common signs. These 2 groups had high percentages of children with titres of antibodies anti HBs above 100 UI/L-1. It is demonstrated the acceptable reactogenecity of the vaccine and the non-immunological interference of other vaccines.

Keywords : HEPATITIS B VACCINES [adverse effects]; HEPATITIS B VACCINE [administration & dosage]; ANTIGEN-ANTIBODY REACTIONS [drug effects]; IMMUNIZATION SCHEDULE; VACCINES, SYNTHETIC; DIPHTHERIA -TETANUS-PERTUSSIS VACCINE; NEISSERIA MENINGITIDIS [immunology]; BACTERIAL VACCINES.