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Revista Cubana de Medicina Tropical

Print version ISSN 0375-0760On-line version ISSN 1561-3054


OROZCO VEGA, Laura Elena; LOPEZ FLORES, Rafael; MOLES Y CERVANTES, Luis Pedro  and  QUIROZ VALIENTE, Jorge. Evaluation of an homologous bacterin against bovine Leptospirosis. Rev Cubana Med Trop [online]. 2005, vol.57, n.1, pp.38-42. ISSN 0375-0760.

48 adult bovine females dividided into 6 groups were used aimed at characterizing the immune response induced in breastfeeeding cows by an homologous bacterin formulated with different adjuvants. They were intramuscularly administered 2 milliliters of a bacterin formulated with Leptospira interrogans serovars uam, wolffi, hardjo, bratislava, grippotyphosa and panama added with different adjuvants, such as aluminum hydroxide, Freud’s complete adjuvant, Freud’s incomplete adjuvant, liposoluble vitamins, bacterin plus disparasitization with levamisol. The control group was administred only with bacterin. Immunization took place in 2 occasions at a time interval of 28 days. Blood samples were taken every 7 days during the first month after vaccination, and every 28 days for the next 8 months. All the sera were analyzed by the microscopic agglutination test. The results were transformed into Log10 and they were analyzed by NLIN and GLM of SAS. The period of greater response was estimated by the prediction model (Wood). The bacterin did not produce alteration either in the physiological constants, or in milk production. The serovars of Leptospira interrogans that induced higher titers were uam, hardjo and wolffi. The statistical difference between treatments and between serovars was determined.

Keywords : Bovine leptospirosis; homologous bacterin; adjuvants; immune response; Chiapas; Mexico.

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