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vol.57 issue1Evaluation of two different potency tests for leptospirosis vaccine vax-SPIRAL®Scale-up of the fermentation of Leptospira interrogans canicola canicola for the production of vax-SPIRAL vaccine author indexsubject indexarticles search
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Revista Cubana de Medicina Tropical

Print version ISSN 0375-0760On-line version ISSN 1561-3054

Abstract

FERNANDEZ ENRIQUE, Kenia et al. Use of diafiltration in the lavage of cultures of Leptospira interrogans canicola canicola for the production of vaccine vax-SPIRAL. Rev Cubana Med Trop [online]. 2005, vol.57, n.1, pp.69-70. ISSN 0375-0760.

It was proposed to substitute the present technology of the lavage operation for a tangential microfiltration system at the lavage stages of the culture of Leptospira interrogans canicola canicola. It was proved that this system may be applied, since no cellular affectation was observed and high pollutant elimination levels were obtained.

Keywords : Vax-SPIRAL; leptospirosis; diafiltration.

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