Abstract

ALVAREZ, Mayling et al. Viral infection sequences related to dengue fever in dengue 3 epidemics occurred in the City of Havana, 2001-2002 . Rev Cubana Med Trop [online]. 2008, vol.60, n.1. ISSN 0375-0760.

OBJECTIVE: To study the role of secondary infection and of certain viral infection sequences in dengue fever cases during the dengue 3 epidemics occurred in the City of Havana. METHODS: One hundred and forty one laboratory-confirmed clinical samples from dengue 3 cases were studied. According to WHO criteria, all included cases were classified as dengue fever cases; 101 of these samples were collected at the acute phase of the disease whereas 40 were collected in the late convalescence (16 to 18 months after the onset of disease). RESULTS: The late convalescence serum samples allowed identifying the viral dengue infection sequences, which in downward order were DENV-1/DENV-3, DENV-2/DENV-3 and DENV-1/DENV-2/DENV-3. CONCLUSIONS: The results confirmed that the sequence infection DENV-2 / DENV-3 was associated with Dengue Fever Cases but not with the Dengue Hemorrhagic Fever Cases and that a high percentage of studied cases proved to be secondary infection.

Keywords : Dengue fever; viral infection sequences; sera; neutralizing antibodies; Cuban epidemic 2001-2002; PNRP.

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