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Revista Cubana de Medicina Tropical
On-line version ISSN 1561-3054
Abstract
LIEM HERRERA, Nuris et al. Diagnostic importance of cerebellar progressive multifocal leukoencephalopathy. Rev Cubana Med Trop [online]. 2021, vol.73, n.3 Epub Dec 01, 2021. ISSN 1561-3054.
Introduction:
Progressive multifocal leukoencephalopathy is a demyelinating disease of viral etiology that affects the central nervous system. It presents in patients with immunosuppressive conditions and location in the posterior fossa is rare. Due to its unspecific clinical forms, its diagnosis is infrequent, leading to irreversible damage and/or the patient's death.
Objective:
Instruct about the possibility of cerebellar progressive multifocal leukoencephalopathy in immunocompromised patients with neurological manifestations of posterior fossa damage.
Clinical case:
A case is presented of a male 25-year-old patient without apparent pathological antecedents who started out with slurred speech, mixed tremor, dysmetria and ataxia. Cerebellar progressive multifocal leukoencephalopathy was diagnosed by clinical picture, neuroimaging and the presence of JC virus in the cerebrospinal fluid, alongside severe immunosuppression caused by human immunodeficiency virus diagnosed by serological testing.
Keywords : progressive multifocal leukoencephalopathy; immunodepression; JC virus; opportunistic disease.