Abstract

HERNANDEZ PADRON, Carlos et al. Complement system and circulating immune complexes in multiple myeloma. Rev Cubana Hematol Inmunol Hemoter [online]. 1999, vol.15, n.2, pp. 114-120. ISSN 1561-2996.

39 patients with multiple myeloma (12 IgA and 27 IgG) in different stages of the diseases were studied. 9 were in stages I + II and 30 in stage III. As regards the clinical phases, 17 were in active early phase, 7 in steady phase, 8 in relapse and 7 in refractory phase. The hemolytic activity of the classical pathway, of the alternative pathway and of the complement factor B was evaluated. Components C3 and C4 were quantitated and the presence of circulating immune complexes was determined. A significant reduction of the hemolytic activity of the alternative pathway (p=0.0002), of the hemolytic activity of factor B (p=0.00001), and of the serum levels of C3 (p=0.00001) was proved. These alterations occurred regardless of the type of paraprotein and of the stage and cinical phase of the studied patients

Keywords : MULTIPLE MYELOMA [immunology]; COMPLEMENT PATHWAY; CLASSICAL; COMPLEMENT PATHWAY; ALTERNATIVE; PROPERDIN FACTOR B; COMPLEMENT 3; COMPLEMENT 4; ANTIGEN-ANTIBODY COMPLEX.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )