Abstract

ALFONSO VALDES, María Elena et al. Anti-D IgG titer and concentration in the hemolytic disease of the fetus and newborn. Rev Cubana Hematol Inmunol Hemoter [online]. 2000, vol.16, n.2, pp.105-114. ISSN 0864-0289.

The prenatal prediction of the hemolytic disease of the fetus and newborn and the severity of this disease by non-invasive methods is highly important for the early adoption of measures that avoid or minimize fetal damage. We made a retrospective study of medical histories data and lab results of 14 Rh D-negative women in which the relationship between serum anti-D IgG antibodies titers, determined by indirect antiglobulin test during the three pregnancy trimesters, and the effects of the hemolytic disease on fetus and newborn was analyzed. An immunoenzymatic method was introduced to measure anti-D IgG concentrations in lab-preserved sera collected at the end of the last pregnancy trimester. It was concluded that the variations of antibody titers from the first to the second trimester and from the first to the third trimester are useful for the prediction of fetal-neonatal effects. Anti-D IgG concentration was higher than 4 Ul/mL in all the cases with clinical affection and increased with the severity of the disease. This method is proposed to be introduced in the follow-up of RhD negative pregnant women

Keywords : ERYTHROBLASTOSIS , FETAL [prevention and control]; RHO(D) IMMUNE GLOBULIN; ENZYME- LINKED IMMUNOSORBENT ASSAY.

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