Abstract

JAIME FAGUNDO, Juan Carlos et al. Uremic haemolytic syndrome. Rev Cubana Hematol Inmunol Hemoter [online]. 2003, vol.19, n.2-3, pp. 0-0. ISSN 1561-2996.

It was made a review of the general aspects of the uremic haemolytic syndrome (UHS): epidemiology, pathogeny, clinical manifestations and treatment. UHS results from the action of numerous ethiological and pathogenic factors It is mainly caused by a verotoxin produced by different Escherichia coli strains. In this entity, it is produced an endothelial damage that generates a series of phenomena, such as adhesion, platelet aggregation and deposits of fibrin, leading to the formation of thrombi in the microcirculation: thrombotic microangiopathy. UHS is characterized by a combination of acute renal failure, thrombocytopenia and microangiopathic haemolytic anemia. Diarrheas and upper respiratory tract infections are the most common precipitating factors. Plasmaphaeresis and dialysis are nowadays the election treatment

Keywords : HEMOLYTIC-UREMIC SYNDROME [epidemiology]; HEMOLYTIC-UREMIC SYNDROME [etiology]; HEMOLYTIC-UREMIC SYNDROME [drugtherapy]; ESCHERICHIA COLI; KIDNEY FAILURE, ACUTE; TROMBOCYTOPENIA; ANEMIA, HEMOLYTIC; CHILD.