Abstract

FORRELLAT BARRIOS, Mariela; FERNANDEZ DELGADO, Norma  and  HERNANDEZ RAMIREZ, Porfirio. New knowledge of iron metabolism. Rev Cubana Hematol Inmunol Hemoter [online]. 2005, vol.21, n.3. ISSN 0864-0289.

Iron is a very important mineral for the organism and its regulation requires a complex molecular network. Only 3 proteins that took part in iron metabolism were known a few years ago, but in the last decade, new proteins that participate in iron homeostasis and that are involved in its transportation, absorption, recycling and balance in the organism have been discovered in a sequential way, starting from the study of some genetical diseases, such as hereditary hemochromatosis. The identification and isolation of these proteins lead inevitably to the modification of the classical models of regulation of the homeostasis of this powerful mineral. A review of the esential elements known up to now of each of these new proteins and the interaction among them was made in this paper

Keywords : Iron; hepcidin; HFE; hemojuvelin.