My SciELO
Services on Demand
Article
Indicators
- Cited by SciELO
Related links
- Similars in SciELO
Share
Revista Cubana de Hematología, Inmunología y Hemoterapia
On-line version ISSN 1561-2996
Abstract
PAVON MORAN, Valia; HERNANDEZ RAMIREZ, Porfirio; JAIME FAGUNDO, Juan Carlos and AGRAMONTE LLANES, Olga. Imatinib in chronic myeloid leukemia. Rev Cubana Hematol Inmunol Hemoter [online]. 2005, vol.21, n.3, pp. 0-0. ISSN 1561-2996.
Chronic myeloid leukemia (CML) was the first neoplasia in which it was possible to present a model of genotype that served as a target for a molecular action therapy. The activation of multiple ways of transduction signals in the cells with the BCR-ABL gene favors the increase of the cellular proliferation, interferes the apoptosis, and perturbs the interaction with the extracellular matrix and the stroma. The introduction of Imatinib in the treatment of CML has modified the evolution and prognosis of this disease. Imatinib has proved to have a high level of efficiency associated with a smaller number of adverse reactions on being compared with the regimens based on interferon and hydroxyurea
Keywords : Chronic myeloid leukemia; Philadelphia chromosome; BCR-ABL; Imatinib.