Abstract

ARENCIBIA NUNEZ, Alberto. To convert the low risk in zero risk in patients with febrile neutropenia. Rev Cubana Hematol Inmunol Hemoter [online]. 2009, vol.25, n.2, pp.29-33. ISSN 0864-0289.

Febrile neutropenia is one of the main causes of mortality in patients presenting with malignant hemopathic disorders; however the clinical and course presentation of this condition differ notably between patients. The first risk stratification model was developed by Talcot from clinical elements and differentiated the patients according the risk of lethal complications. However, around the 10% of patients classed as low risk of severe complications required intrahospital treatment. The determination of some acute phase reactants e.g. reactive C protein, 6 and 8 interleukins, and procalcitonin, increases remarkably the sensitivity and specificity of prognostic model. The new imaging techniques and of molecular biology allow an early and accurate diagnosis of infections in a near future. However, it is necessary to develop prognostic models combining clinical and humoral elements suited to epidemiological conditions of each institution to optimize the differentiated treatment of patients presenting with febrile neutropenia.

Keywords : Febrile neutropenia; risk stratification; acute phase reactants.

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