Abstract

ARENCIBIA NUNEZ, Alberto et al. A new model applied in prediction of febrile neutropenia in children with acute leukemias. Rev Cubana Hematol Inmunol Hemoter [online]. 2009, vol.25, n.2, pp.45-58. ISSN 0864-0289.

A retrospective and analytical control cases study was carried out in 62 episodes of febrile neutropenia present in patients with malignant blood disease admitted in Hematology and Immunology Institute during 2005 and 2006. Above episodes were divided in 2 groups from its favorable course (56%) or unfavorable (44%) as well as the laboratory and clinical parameters compiled in both groups. Factors with higher association related to unfavorable course were the comorbidities presence (sepsis, dehydration, hypoxia, hypovolemia and severe mucositis), diagnosis of non-lymphoblastic, use of chemotherapy during the 7 previous days to fever onset, general status involvement, and the neutrophil absolute count lower than 100 x mm³. Patients presenting with a unfavorable course febrile neutropenia had two poor diagnosis factors. The positive predictive value of prognostic model was of 91,4% and the negative one was of 92,6% with a sensitivity and specificity of 94,1% and 89,3%, respectively.

Keywords : Febrile neutropenia; risk stratification; prognostic models; leukemias.

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