Abstract

MARSAN SUAREZ, Vianed et al. Biological and clinical meaning of myeloid antigen expression in the acute lymphocytic leukemia in children. Rev Cubana Hematol Inmunol Hemoter [online]. 2009, vol.25, n.3, pp. 0-0. ISSN 1561-2996.

In 238 children presenting with acute lymphoid leukemia (ALL) authors studied the possible association between the myeloid antigens expression with determined biologic and clinic features at disease onset. The cellular immunophenotyping was performed by ultraimmunocytochemical method. From the total of diagnosed ALLs, the 21,8% were LLA-Mi+. There was a lymphadenopathies predominance (71,2%), splenomegaly (65,4%) and hepatomegaly (57,7%) in patients with LLA-Mi+ and very significant differences (p =0,003, p = 0,0068, and p = 0,000, respectively. There was also alight predominance of mediastinum adenopathies, CNS infiltration and hemorrahagic manifestations in patients with LLA-Mi+, no statistically significant. Results showed that in our patients the myeloid antigen expression on the lymphoid blasts influenced on appearance of determined presentation of morphologic and clinical features in children.

Keywords : acute lymphoid leukemia; cellular immunophenotyping; myeloid antigen.

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