Abstract

PEREZ-RUIZ, Leslie; RAMOS-CEDENO, Ana M; BOBILLO-LOPEZ, Hailen  and  FERNANDEZ-AGUILA, Julio D. ABO and RhD blood groups in multiple sclerosis. Rev Cubana Hematol Inmunol Hemoter [online]. 2011, vol.27, n.2, pp. 244-251. ISSN 1561-2996.

The physiopathology of multiple sclerosis is uncertain. The best founded hypothesis is the existence of an autoimmune process in which genetic predisposition plays a role. The system of blood groups consists of easily detectable antigens; therefore, it is an excellent genetic marker. To determine the distribution frequency of blood groups in patients with multiple sclerosis, 70 ill persons were studied, about whom demographic, clinical and evolutionary scale data were obtained. 180 controls were selected by simple random multistage sampling of a universe of 4 747 blood donors. Blood groups ABO and RhD were determined. X² was calculated with a 95% accuracy and confidence interval of percent differences. RhD⁺ was more frequent in both groups (85.7 % cases and 90% controls). Blood group A was found in 60 % patients, whereas group O prevailed in donors (55 %), with a significant difference of p=0.003 and OR=2.85. According to this study, there is a relationship between blood group A and multiple sclerosis.

Keywords : Case-control; autoimmune diseases; multiple sclerosis; blood groups.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )