Abstract

SOCARRAS FERRER, Bertha Beatriz et al. Comparison of the activity of 2 domestic- production factors for granulocyte colonies: Hebervital and Leukocim. Rev Cubana Hematol Inmunol Hemoter [online]. 2011, vol.27, n.4, pp. 429-434. ISSN 0864-0289.

In 35 patients who should have received regenerative cell therapy, it was evaluated the effect of 2 domestic production granulocyte colony stimulating factors: Leukocim and Hebervital for the mobilization of hematopoietic stem cells into peripheral blood. Patients were randomly selected into 2 treatment groups and were given a total dose of 40 mg/kg in 4 sub-doses of 10 mg/kg subcutaneously administered every 12 hours. Count was performed for mononuclear cells and CD34+ cells in peripheral blood by flow cytometry before and after stimulation. There were no statistically significant differences in the counts of CD34+ cells obtained after stimulation with Hebervital and Leukocim.

Keywords : Granulocyte colony stimulating-factor; G-CSF; CD34+ cells; mononuclear cells.

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