Abstract

FERNANDEZ-DELGADO, Norma; FORRELLAT-BARRIOS, Mariela; GONZALEZ-SUAREZ, Tania  and  SALGADO-AROCENA, Odalys. Therapeutic plasmapheresis. Two-year analysis at the Institute of Hematology and Immunology. Rev Cubana Hematol Inmunol Hemoter [online]. 2012, vol.28, n.2, pp. 151-168. ISSN 0864-0289.

Therapeutic plasma exchange is an extracorporeal procedure in which, after removing the whole blood, plasma is separated from other cellular components with the aim of reducing or eliminating pathological substances involved in the pathophysiology of the disease. Today, apheresis procedure is the most frequently used in clinical medicine. In this paper, we mention fundamental advances in their indications, methods and replacement solutions. We evaluate indications of plasmapheresis, which were performed at the Institute of Hematology and Immunology from January 2009 to December 2010. There were evaluated 295 plasmapheresis performed in 35 patients with 9 diseases or conditions associated with them. 60 % matched Class I of the American Association of Apheresis (ASFA) and this procedure was effective in 88.6 % of cases. The exchange volume ranged from 750 to 2 400 mL and the most common replacement solution was saline solution, followed by fresh frozen plasma and albumin. 4.06 % of these patients had some adverse reactions related to the proceeding, but these were mild and easily controlled. Plasmapheresis is a procedure with enormous therapeutic benefits when used in diseases, which have proven its effectiveness.

Keywords : therapeutic plasmapheresis; ASFA criteria; replacement volume; replacement volume.

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