Abstract

BRITO-GARCIA, Amparo et al. Anti-HLA antibodies in patients with chronic renal failure awaiting renal transplantation. Rev Cubana Hematol Inmunol Hemoter [online]. 2012, vol.28, n.3, pp.275-281. ISSN 0864-0289.

Performing renal transplantation in sensitized patients is a challenge for transplant programs. In October 2009, an observational, analytical, cross study was performed in patients from Havana on the transplant waiting list, to determine the mortality rate due to lymphocyte anti-HLA antibodies or PRA (panel reactivity antibody) and to identify related factors. Microlymphocytotoxicity technique was used and when PRA % 20 patients were considered not sensitize; sensitized when PRA % 20, and hypersensitive, when PRA % 75. To compare groups of sensitized and non-sensitized patients we used the homogeneity test (qualitative variables) and Student's t test (quantitative variables). Sixty eight not sensitized patients and 60 were sensitized; 43,3% of sensitized patients were candidates for retransplantation, higher value than the one observed in non-sensitized patients (8.8 %) (p = 0.00). In the sensitized group the frequency of transfused patients was 100 % and 86.8 % (p = 0.00) in the non-sensitized ones The average time on the waiting list was 112 months for sensitized patients, significantly higher than the 36 months for the non-sensitized group (p = 0.00). Possible factors related to patient sensitization were transfusion administration, time in the transplant waiting list and number of transplants received.

Keywords : anti-HLA antibodies; chronic renal failure; renal transplant.

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