Abstract

ZAMORA-GONZALEZ, Yaneth; AGRAMONTE-LLANES, Olga M  and  RODRIGUEZ-PEREZ, Loreta. Deficiency of proteins C and S: trombotic risk markers. Rev Cubana Hematol Inmunol Hemoter [online]. 2013, vol.29, n.1, pp. 40-47. ISSN 0864-0289.

For several centuries it has been known that coagulation defects cause hemorrhagic disease, but the study of its counterpart, thrombotic diseases, has been developed in more depth just a few decades ago. These disorders of coagulation system are one of the most common causes of death in the world today, where about two million people die every year from thrombosis, either arterial or venous. They are also considered an important source of morbidity in people who suffer it and survive. Hypercoagulable state or thrombophilia are clinical conditions that affect a number of patients with abnormal tendency to thrombotic events. Deficiency of protein C (PC) and protein S (PS) are causes of congenital or acquired thrombophilias that predispose to thromboembolic disorders, recurrent pregnancy loss, recurrent venous thrombosis, among others. Its diagnosis is very important it provides tools for its prophylaxis in order to reduce the risk of recurrence and the possibility of identify a carrier state in any other family member.

Keywords : proteins C and S; thrombosis; thromboembolism.

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