Abstract

VELEZ TOBON, Gabriel Jaime; ROCHA ARRIETA, Yermis Carolina; ARIAS SIERRA, Andrés Augusto  and  LOPEZ QUINTERO, Juan Álvaro. Role of nadph oxidase system in the neutrophil extracelular Traps (NETs) formation. Rev Cubana Hematol Inmunol Hemoter [online]. 2016, vol.32, n.1, pp. 43-56. ISSN 1561-2996.

Neutrophil extracellular traps (NETs) are structures mainly composed of chromatin and granule proteins that once released constitute a defense mechanism due to their ability to trap and destroy pathogen microorganisms. The process by which these structures are released is known as NETosis and in case this may lead to cell death is different to apoptosis and necrosis. Although all the molecular events involved in the formation of NETs are poorly understood, it is known that depending on the stimulus, reactive oxygen species (ROS) are essential to the chromatin decondensation and subsequent NETs formation.

Keywords : neutrophil extracellular traps; NETs; chronic granulomatous disease; CGD.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )