Abstract

TRIANA MARRERO, Yenisey; MARSAN SUAREZ, Vianed; SANCHEZ BALLESTER, Amanda  and  DIAZ DOMINGUEZ, Gabriela. B-cell chronic lymphoid leukemia: a review of its etiopathogenic, molecular and prognostic aspects. Rev Cubana Hematol Inmunol Hemoter [online]. 2019, vol.35, n.1 ISSN 1561-2996.

Chronic lymphocytic leukemia (CLL) is a malignancy that mainly affects middle-aged and elderly patients. It is characterized by the proliferation of morphologically mature but immunoincompetent lymphocytes that accumulate in blood, bone marrow and lymphatic tissue. It presents great clinical heterogeneity. Several phenotypes are described, although the clonal expansion of CD5 + CD23 + B cells predominates. Prognostic factors include the cytogenetic subgroup, immunoglobulin mutational status, expression of ZAP-70, CD38, and CD49d. The treatment is based on using modern approved therapeutic algorithms that produce greater responses and minor secondary events, to achieve complete clinical remission and to improve the quality of life of these patients.

Keywords : chronic lymphocytic leukemia; immunophenotype; prognostic factors.

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