Abstract

RIVERO JIMENEZ, René Antonio. Exosomes: “cell-free” regenerative cell therapy. Rev Cubana Hematol Inmunol Hemoter [online]. 2020, vol.36, n.2, e1133.  Epub Oct 01, 2020. ISSN 0864-0289.

Mesenchymal/stromal cell‒based therapy is widely applied in modern medicine, even though not all survival and differentiation mechanisms are identified. However, a few years ago, extracellular elements began to be found that generate new paradigms. The present work explains the main characteristics and functions attributed to exosomes, nanoparticles made up of microvesicles secreted by with an effect on the extracellular matrix, and their impact as an alternative towards cell-free regenerative medicine. These structures participate, notoriously and critically, in intercellular communication, which has led to a change in the concept of the functions and role that these vesicles play within living organisms, particularly in the restoration of damaged tissues and the inflammatory and immunological response. Some examples of the exosomes’ biotechnological impact on companies and the biopharmaceutical market are discussed.

Keywords : exosomes; extracellular vesicles; nanoparticles; mesenchymal cells.

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