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Revista Cubana de Hematología, Inmunología y Hemoterapia
Print version ISSN 0864-0289On-line version ISSN 1561-2996
Abstract
TELLO VERA, Stalin; DE MATOS CORREIA EVALE, Alberto Orfao and CARPIO VASQUEZ, Wendy del Carmen. Acute leukemia of mixed phenotype: presentation of a pediatric case from Peru. Rev Cubana Hematol Inmunol Hemoter [online]. 2022, vol.38, n.1, e1459. Epub Apr 15, 2022. ISSN 0864-0289.
Introduction:
Acute leukemias of ambiguous lineage represent a heterogeneous group of leukemias without a clear differentiation of the cell lineage. They constitute about 2 to 5 % of all acute leukemias.
Objective:
To describe a case of acute leukemia of mixed phenotype (LAFM) in a 4-year-old pediatric patient from Lambayeque, Peru.
Case presentation:
A peripheral blood sample from a 4-year-old boy was evaluated, whose immunophenotype by flow cytometry showed a population, corresponding to 94 % of total cellularity, of myeloid lineages compatible with differentiation to neutrophil lineage and in less to monocytic/dendritic cell (CD123 high), with expression of myeloperoxidase (MPO) and CD33 high; CD13, CD64 and CD66c partial; and expression of B lymphoid lineage markers (CD19 and CD22 high). This phenotype requires ruling out the t (8; 21), and abnormalities of the MLL gene. Due to the aforementioned findings, the present leukemia was classified as acute leukemia of mixed phenotype, B/Myeloid.
Conclusions:
It was concluded as an acute leukemia of mixed phenotype B/Myeloid, with the peculiar inclination of the myeloid lineage towards neutrophils and to a lesser extent towards monocytic/dendritic cell.
Keywords : acute leukemia; acute biphenotypic leukemia; acute myeloid leukemia.