Introduction:

The increase in life expectancy of patients with sickle cell disease causes co-morbidities and chronic organ dysfunction to be added to the clinical manifestations of the disease.

Objectives:

To analyze the renal, neurological and sensory alterations that appear in patients with sickle cell disease as manifestations of chronic organic dysfunction.

Methods:

A review of the articles published in the last ten years was carried out using the search engines PubMed, SciELO and Google Scholar. The search terms were: sickle cell disease, organ dysfunction, mortality, proteinuria, chronic kidney disease, silent cerebral infarction, neurocognitive disorders, retinopathy, sensorineural deafness

Analysis and synthesis of information:

The combined effect of glomerular, tubular and interstitial involvement leads to a gradual decline in kidney function. Progression to end-stage chronic kidney disease is common and is associated with increased mortality. Central nervous system complications can also have a negative impact on survival or cause sequelae that influence the quality of life of patients. Sensory impairments have biopsychosocial repercussions. Aspects related to the prevalence, diagnosis and treatment of these complications are described.

Conclusions:

A follow-up of patients based on strategies to prevent and diagnose early the manifestations of chronic organ dysfunction can reduce the unfavorable consequences of these complications.

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