Abstract

FLORES GONZALEZ, Julia; MARTINEZ GARCIA, Rolando; HERRERA ESTUPINAN, Soledad  and  LARRONDO MUGUERCIA, Hilev. Clonidina oral en la medicación preanéstesica del paciente hipertenso. Rev Cubana Invest Bioméd [online]. 1996, vol.15, n.1. ISSN 0864-0300.

A study is designed to assess the efficacy and safety of clonidine as preanesthetic medication for the hypertensive patient. Fifty inpatients going through elective major surgery were treated; they had between 20 and 65 years old, both sexes, tension figures in 140/90 or more, class II of ASA risk, and they were randomly assigned to clonidine treatment or oral placebo in a prospective double blind assay. A dose of 0,075 mg clonidine was administered 8, 12 and 16 hours before the surgical procedure. There were no statistically significant differences between both groups with respect to age, sex, values of systolic tension, diastolic, initial mean or radial pulse. Such parameters were assessed every 6 hours at pre and postoperatory. Clonidine decreased the tension figures in both periods. Adverse reactions without clinical importance occurred in the 27 % of the cases. Drowsiness was the most common secondary effect. No orthostatic hypotension cases were detected. The alpha-agonist reduced the frequency of hypertensive reactions in the postoperatory period (34 %) compared with the placebo (58 %).

Keywords : PREANESTHETIC MEDICATION; CLONIDINE [therapeutic use]; CLONIDINE [adverse effects]; HYPERTENSION [chemotherapy].