Abstract

SIMON CARBALLO, Rafael; FLEITAS ESTEVEZ, Andrés; ALVAREZ, José A.  and  RODRIGUEZ, Gerardo. Comparación del efecto hipocolesterolémico de la colestina con la colestiramina. Rev Cubana Invest Bioméd [online]. 1997, vol.16, n.1, pp. 30-33. ISSN 1561-3011.

The hypocholesteremic effect of cholestyramine was compared with that of cholestene, 2 drugs of similar action mechanism, in rabbits from New Zealand that were administered a 2 % dose of these products through the feed during 45 days. At the end of the study, a significant reduction (p < 0,01) of the serum cholesterol concentrations was found in the group of animals that received cholestyramine and cholestene compared with the pretreatment levels and with the control group. The serum cholesterol reduction obtained with both drugs were of 35,5 and 36, respectively. No considerable changes were observed in the rest of the lipidic variables. The results show that the cholesteremic effect of cholestene is similar to that of cholestyramine.

Keywords : CHOLESTYRAMINE [therapeutic use]; ANTICHOLESTEREMIC AGENTS [therapeutic use]; CHOLESTEROL [blood]; LIPOPROTEINS, HDL CHOLESTEROL [blood]; TRIGLYCERIDES [blood]; RABBITS; STATISTICAL ANALYSIS.