Abstract

GUANCHE GARCELLS, Humberto; ROMAN ALDAMA, Wilfrido; VALES GARCIA, Manuel  and  GOMEZ CALA, Adolfo. Efectos metabólicos de la asociación glibenclamida-metformín en diabéticos obesos. Rev Cubana Invest Bioméd [online]. 1997, vol.16, n.1, pp. 55-58. ISSN 1561-3011.

The association of metformin hydrochloride with sulphonylureas has been used when it is not possible to control the patient with sulphonylureas as a monotherapy. In the present paper it was evaluated the effect of the combination of metformin and glibenclamide on glycemia, cholesterolaemia and triglyceridemia in non-insuline dependent obese diabetic patients hard to control. There was a control of glycemia as well as a reduction of cholesterolaemia and triglyceridemia after the second month of treatment. It is concluded that the therapeutics used was useful to control obese diabetic patients resistant to glibenclamide.

Keywords : DIABETES MELLITUS, NON-INSULIN DEPENDENT [drug therapy]; OBESITY IN DIABETES; GLYBURIDE [therapeutic use]; METFORMIN [therapeutic use]; BLOOD GLUCOSE [analysis]; TRIGLYCERIDES [blood]; CHOLESTEROL [blood]; DRUG THERAPY, COMBINATION.