Abstract

BROCHE VALLE, Félix; CESPEDES MIRANDA, Ela M; SALDANA BERNABEU, Alberto  and  CRUZ PEREZ, Arturo L. La enfermedad por quemaduras como modelo  de respuesta inflamatoria sistémica. Rev Cubana Invest Bioméd [online]. 1999, vol.18, n.2, pp. 77-85. ISSN 1561-3011.

A body burn is a violent agression that modifies all the mechanisms of organic homeostasis and is also a problem facing the medical services in the contemporary society because of its clinical and social connotation. From the physiopathological viewpoint, a burned patient develops a systemic inflammatory response characterizaed by hyperactivation of all its defense mechanisms. The de-regulation of such mechanisms leads to damage of tissues which is expressed as morpho-functional modifications of all systems. Regardless of the ethiology, initial evolution, therapeutic management and individual response, sepsis generally complicates the evolution of burn injuries. This paper sets forth the clinical and histopathological elements of burn-related diseases and comments on the molecular mechanisms of systemic inflammatory response, underlining the role of the intercellular signalling mediators.

Keywords : BURN [pathologic]; SEPSIS SYNDROME [physiopathology].

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