Abstract

CESPEDES MIRANDA, Ela; RODRIGUEZ CAPOTE, Karina; LLOPIZ JANER, Niurka  and  CRUZ MARTI, Niurys. Un acercamiento a la teoría de los radicales libres y el estrés oxidativo en el envejecimiento. Rev Cubana Invest Bioméd [online]. 2000, vol.19, n.3, pp. 186-190. ISSN 1561-3011.

The increase of life expectancy has caused an aging of the population and consequently a relative rise of the diseases associated with it. During the last years more studies have been conducted on this topic and numerous hypotheses have been made. In this paper some theories on aging are presented, among them, those ones programmed from the genetic point of view that state that aging occur in a predetermined way, and the theories on non-genetically programmed aging, in particular, the theory of free radicals and oxidative stress, whose central dogma is based on how during the aerobial metabolism radical species derived from oxygen are produced incidentally and in an uncontrollable way, the molecules are irreversibly damaged, damage that is accumulated in the course of time, and this results in a gradual lost of the homeostatic mechanisms, interference of the patterns of genic expression and lost of the functional capacity of the cell

Keywords : LIFE EXPECTANCY; DEMOGRAPHIC AGING; AGING [genetics]; FREE RADICALS; OXIDATIVE STRESS.

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