Abstract

LEON PEREZ, David  and  LARRONDO MUGUERCIA, Hilev. Medicina crítica y estrés oxidativo. Rev Cubana Invest Bioméd [online]. 2000, vol.19, n.3, pp. 196-198. ISSN 1561-3011.

Reactive oxygen species take part in a large number of diseases and produce direct or indirect damage to different organs. A series of affections among which the respiratory distress syndrome of the adult (RDSA), the acute myocardial infarction (AMI) and the ischemic cerebral vascular accidents are taken as an example are observed in the critically ill patient. The respiratory distress syndrome is an acute inflammatory affection where the pulmonary vascular endothelium is altered with an excessive accumulation of polymorphonuclears in the interstitial and alveolar spaces, a process that is favored by the reactive oxygen species that cause the tissue damage. The respiratory distress syndrome is caused by multiple affections: polytrauma, sepsis, shock states, polytransfusions, etc., and mortality is always high. The acute myocardial infarctions and the cerebral infarctions are an example of diseases in which the ischemia-reperfusion syndrome is present and the tissue damage is produced, provoking an ischemic lesion that compromises the capacity to control oxygen metabolism. In the reperfusion stage an excessive release of reactive oxygen species occur that on interacting with the cellular membrane unchains the so-called process of lipid peroxidation, destruction and cellular death

Keywords : OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; CRITICAL CARE; RESPIRATORY DISTRESS SYNDROME; ADULT [metabolism]; MYOCARDIAL INFARCTION [metabolism]; CEREBRAL INFARCTION [metabolism]; LIPID PEROXIDATION; CELL DEATH.

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