Abstract

VICEDO TOMEY, Agustín  and  VICEDO ORTEGA, Yoryana. Relaciones del estrés oxidativo con el catabolismo de proteínas. Rev Cubana Invest Bioméd [online]. 2000, vol.19, n.3, pp.206-212. ISSN 0864-0300.

Nowadays, there are evidences that make us know that the relations among the free radicals, the proteins and the mechanisms of proteolysis are much more complex than what was initially thought. Today, different proteins are considered not only as the target of the action of the free radicals, but they can also behave themselves as generators and propagators of these harmful susbtances. Likewise, the effects of oxidative stress not only modify the properties of the proteins considered as substrates of the mechanisms of proteolysis, but they can affect the proteolytic mechanisms as such, including the lysosomal and proteosomal pathways and those of the calpains in the intracellular protein catabolism. In this paper it was proposed an integrating view of these alternatives and it was pretended to consider all the varied range of possibilites of interaction that may occur in the free radicals - proteins - proteolysis triangle. This scheme may be very useful from the methodological point of view on analyzing the experimental results attained in this field, as well as on approaching their interpretation

Keywords : OXIDATIVE STRESS; FREE RADICALS; CALPAIN; CELL AGING.

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