Abstract

MORRIS QUEVEDO, Humberto J. et al. Applications of the colloidal carbón clearence technique in peripheral blood in the evaluation of the immunomodulator activity of two natural products. Rev Cubana Invest Bioméd [online]. 2008, vol.27, n.1, pp. 0-0. ISSN 1561-3011.

In this paper, the effect of two natural products in the activity in vivo of the splenic macrophages and the Kupffer's cells was evaluated in different experimental systems by means of the colloidal carbon clearance test in peripheral blood. The results evidenced the stimulating effect of a protein hydrolizate of the microalga Chlorella vulgaris 87/1 on the monocyte-macrophagic system, administered as a supplement to malnourished mice, and of extracts obtained from edible mushrooms Pleurotus spp. in three biomodels of secondary immunodeficiencies (induced by cyclophosphamide, by exposure to ionizing radiations and by protein-energy malnutrition). In the animals treated with the products, it was observed a shorter time of mean life of the particles of colloidal carbon in blood, which shows the immunopotentiating activity of both biopreparations and of the applicability of the technique.

Keywords : Monocyte-macrophagic system; colloidal carbon; splenic macrophages; Kupffer's cells; natural products.

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