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Revista Cubana de Investigaciones Biomédicas

Print version ISSN 0864-0300On-line version ISSN 1561-3011


GONZALEZ GAY, Olivia Teresa et al. Effects of treatment with Compvit B, orotic acid or their combination on the recovery of spatial memory in rats with fimbria-fornix lesion. Rev Cubana Invest Bioméd [online]. 2011, vol.30, n.2, pp.194-207. ISSN 0864-0300.

Vitamin therapies have been widely used in Neurology for the treatment of neuritis or the correction of metabolic deficits. In Cuba, Compvit® (B1, B6 and B12 vitamins) have been produced since several years. Orotic acid, also called vitamin B13 is a natural product showing nootropic actions in studies with young and old cognitively impaired animals. The present paper reports the results of a study conducted to assess the therapeutic potentials of Compvit® and orotic acid, in the recovery of cognitive abilities in fimbria-fornix lesioned animals, a lesion known to severely impair learning abilities. The results confirm positive effects of each vitamin treatment to improve the cognitive abilities affected by lesion. Although none of the products used, neither their combination, was able to raise the cognitive performance to the level of non-lesioned animals, both of them achieve significant improvement compared to placebo. The present paper constitutes additional evidence favoring the therapeutic use of vitamin compounds as part of neurorestorative treatments.

Keywords : Vitamins; Compvit B; orotic acid; fimbria-fornix lesion; learning; neurologic restoration.

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