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Revista Cubana de Investigaciones Biomédicas

Print version ISSN 0864-0300On-line version ISSN 1561-3011


GONZALEZ GAY, Olivia Teresa et al. An experimental method to injure a peripheral nerve and to evaluate recovery and the effect of restorative treatments using behavioral techniques. Rev Cubana Invest Bioméd [online]. 2011, vol.30, n.2, pp.260-270. ISSN 0864-0300.

The paper describes a simple method to injure the peripheral sciatic nerve by clamping, along with a behavioral test to asses the lesion and its recovery using the gait on a metallic grid. Sciatic nerve lesion impairs the displacement of the animals on this surface as demonstrated by the significant increase in the escape latency towards the room cage and the increased number of stance failures with the injured leg. Using this method we assessed the effect of post-injury administration of Compvit B® (vitamin compound) and orotic acid (a pyrimidine-nucleotide precursor) on the recovery of injured nerve. Both treatments and its combination, improved significantly the recovery of injured nerve compared to controls treated with saline solution.

Keywords : Sciatic nerve; regeneration; vitamins; Compvit B; orotic acid.

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