Abstract

ARCE GUERRERO, Sandra; VALENCIA LLANO, Carlos  and  GARZON-ALVARADO, Diego Alexander. Development of a biocomposite made up of tricalcium phosphate and chitosan to be used as bone substitute in an animal model. Rev Cubana Invest Bioméd [online]. 2012, vol.31, n.3, pp.268-277. ISSN 0864-0300.

The research deals with the development of a biocomposite from a ceramic matrix and a polymer with the purpose of using it as bone filler. A mixture was made of the ceramic matrix, tricalcium phosphate Ca (OH)2 and chitosan, a polymer of natural origin. The mixtures underwent preliminary testing to choose 4 types of biocomposites (BC1, BC2, BC3, BC4) with varying proportions of ceramic matrix elements. The biocomposite was prepared at a pH between 6.5 and 8.5. Drying time ranged between 7 and 20 minutes. Optimal samples were chosen and their mechanical properties analyzed by means of compression resistance testing. PH measurements showed values between 7.05 and 7.6, and drying times ranged between 7 and 15 minutes. The paste remained at a constant temperature of 25 ºC and maintained molding consistency. These properties are required for use as bone substitute. The sample exhibiting the best pH, temperature and drying time values was chosen for implantation in rabbit tibiae to verify the histological response after 60 days.

Keywords : bone regeneration; bone substitute; biocomposite; tricalcium phosphate; chitosan.

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