Abstract

LOPEZ-VACA, Oscar Rodrigo  and  GARZON-ALVARADO, Diego Alexander. Representation of the development of the primary spongiosa by means of a reaction-diffusion system: a hypothesis on the onset of immature bone formation. Part 1: Model description. Rev Cubana Invest Bioméd [online]. 2012, vol.31, n.3, pp.290-296. ISSN 0864-0300.

A biochemical model is presented which predicts the formation of the architecture of the primary spongiosa, based on the interaction of two molecular factors: VEGF (vascular endothelial growth factor) and MMP-13 (metalloproteinases-13). It is assumed that MMP-13 regulates cartilage degradation, and VEGF allows vascularization and the advance of the ossification front through the presence of osteoblasts. The coupling of this set of molecules is represented by means of reaction-diffusion equations with Turing space parameters, and a stable spatio-temporal pattern is obtained which leads to the formation of the trabeculae present in the spongy tissue.

Keywords : primary spongiosa; endochondral ossification; reaction-diffusion systems.

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