Abstract

GARZON-ALVARADO, Diego Alexander; VELASCO PENA, Marco Antonio  and  NARVAEZ-TOVAR, Carlos Alberto. Modeling of the hydrolytic degradation of a bone implant. Rev Cubana Invest Bioméd [online]. 2012, vol.31, n.3, pp.318-331. ISSN 0864-0300.

Research into bone tissue regeneration and substitution is one of the most important components of tissue engineering. In compliance with these requirements, bone implants have been developed which allow cell migration, tissue growth, the transport of growth factors and nutrients, and the renewal of mechanical properties. Implants are made of various biomaterials, and they have been manufactured using techniques which not always allow total control of the size and orientation of the pores involved in the microstructure of the scaffold. From this standpoint, a reaction-diffusion system is proposed for the achievement of appropriate geometric features in the bone matrix. The hypothesis is validated through simulations of the geometry obtained with a reaction-diffusion system and a model of hydrolytic degradation in three-dimensional representative elements.

Keywords : reaction-diffusion; bone; structural scaffolds; ossification; healing.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )