Abstract

NINO BARRERA, Javier Laureano  and  GARZON-ALVARADO, Diego Alexander. Morphogenesis of dentinal tubules: a mathematical model. Rev Cubana Invest Bioméd [online]. 2012, vol.31, n.3, pp.352-362. ISSN 0864-0300.

Mesenchymal differentiation into odontoblasts is a complex process determining the formation of dentinal tubules. The process involves a carefully regulated sequence of changes in the behavior of mesenchymal cells, coordinated by the expression of various molecular factors, particularly Noggin and BMP2. In this paper the formation of dentinal tubules is simulated using a reaction-diffusion mathematical model solved by the finite element method.

Keywords : dentinal tubules; odontoblasts; BMP2; Noggin.

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