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Revista Cubana de Investigaciones Biomédicas

Print version ISSN 0864-0300On-line version ISSN 1561-3011


MORALES GONZALEZ, Maraelys et al. Effects of low-intensity electric current on healthy mice. Rev Cubana Invest Bioméd [online]. 2019, vol.38, n.4, e308.  Epub Feb 28, 2020. ISSN 0864-0300.


Knowledge about the effects of electrochemotherapy on organisms may be important for the treatment of various diseases.


Evaluate the effects of low-intensity direct electric current on healthy mice.


Eighty healthy C57BL/6/Cenp mice (40 male and 40 female) were randomly distributed in eight experimental groups (four control and four treated). Direct electric current (10 mA during 5 min) or constant voltage (10 V during 5 min) was applied to the mice. Clinical, macroscopic and microscopic observation was performed, and measurements were taken of hematological and biochemical parameters of the blood.


Reversible changes were induced in hematological, biochemical and histological parameters of the blood of male and female C57BL/6/Cenp mice when 10 mA or 10 V and various electrode arrays were used. These changes were less noticeable in the constant voltage mode.


The alterations induced by low-intensity direct electric current in healthy C57BL/6/Cenp mice are reversible. The systemic inflammatory process is dominated by the lymphocytes.

Keywords : electrochemotherapy; inflammation; direct electric current mode; constant electric voltage mode; healthy C57BL/6/Cenp mice.

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