Resumo

RAPADO RANEQUE, Manuel; RODRIGUEZ RODRIGUEZ, Alejandro  e  PENICHE COVAS, Carlos. Hydrogel wound dressing preparation at the laboratory scale by using electron beam and gamma radiation . Nucleus [online]. 2013, n.53, pp.24-31. ISSN 0864-084X.

The present work describes the preparation of hydrogel based on cross-linked networks of poly (N-vinylpirrolidone), PVP, with polyethyleneglicol and agar with 90% water and PVP nancomposites with a synthetic nanoclay, Laponite XLG, for use as burn dressings. These systems were obtained in two ways: using gamma Co-60 and electron beam radiation.  The gelation obtained dose was D_g= 1.72 kGy. The elastic modulus of hydrogel was independent of the method of irradiation. It was 0.39 MPa for the hydrogel irradiated with gamma Co-60 and 0.38 MPa for electron beam irradiation. The elastic modulus of the nanocomposite membrane was 1.25 MPa, three times higher. These results indicate that the PVP/Laponite XLG nanocomposite hydrogel membrane is the best choice for wound dressing applications due to its high water sorption capacity and its superior mechanical properties. 

Palavras-chave : hydrogels; PVP; burns; gamma radiation; electron beams; cobalt 60.

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