SciELO - Scientific Electronic Library Online

 issue60Molecular imaging of cancer microenvironmentSinthesys and toxicity of poly (2-hydroxyethyl methacrylate-co-acrylamide) hydrogels obtained by gamma photon irradiation author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand



  • Have no cited articlesCited by SciELO

Related links

  • Have no similar articlesSimilars in SciELO



On-line version ISSN 2075-5635


ALBERTI RAMIREZ, Alejandro; GARCIA RODRIGUEZ, Enrique; CRUZ ARENCIBIA, Jorge  and  MORIN ZORRILLA, José. Phosphorous-32 and Yttrium-90 as options in the treatment of metastatic bone pain. Nucleus [online]. 2016, n.60, pp. 24-28. ISSN 2075-5635.

In this paper the prevalence of metastatic bone pain is estimated in our country in no less than 3 750 patients. Moreover, the role of Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e01066016.jpg-phosphate, which effectiveness is comparable to other radiopharmaceuticals, and the possible return to its previous general use, as it is cheaper, is examined. The fact that Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e01066016.jpgis considered more radiotoxic doesn’t invalidate it as a treatment option, which is also evidenced by the Cuban experience. The Center of Isotopes (Centis) has established a production line of up to 37 GBq (1 Ci) per week of high quality Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e02066016.jpg. The fact of its being obtained through a radionuclide generator by electrochemical separation from Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e03066016.jpgmakes the import of radioactive raw material practically not required for indefinite time. This implies that the radionuclide could be available in a sustainable way. By having the Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e02066016.jpggreater β- emission energy, it might be more radiotoxic than Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e01066016.jpg. Nevertheless, some evidences show that Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e01066016.jpgin the form of orthophosphate is more radiotoxic than 90Y citrate. In Europe, a radiopharmaceutical consisting of a lyophilized kit of EDTMP and Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e02066016.jpgChloride solution was able to relief pain in 191 patients. Centis has registered the Descripción: Descripción: Descripción: http://img/revistas/nuc/n60/img/e02066016.jpgchloride solution for labeling. Then the task is to introduce in the market a radiopharmaceutical with this radioactive precursor and the imported lyophilized kit in order to increase the treatment to an important number of patients that, as a result, could be benefitted

Keywords : radiopharmaceuticals; skeleton; pain; metastases; phosphorus 32; yttrium 90; bone tissues.

        · abstract in Spanish     · text in Spanish     · Spanish ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License