Abstract

RODRIGUEZ CANOSA, José et al. Cuantificación de IGG contra los componentes inmunogénicos de VA-ENGOC-BC en plasma de lactantes vacunados. Rev Cubana Med Gen Integr [online]. 1997, vol.13, n.2, pp.143-149. ISSN 0864-2125.

Due to the particular characteristics of the immune response in infants and to the efficacy shown by the Cuban antimeningococcal vaccine denominated VA-MENGOC-BC, we propose ourselves to quantify the response of immunoglobulin G against the immunogenic components of the meningococci B and C present in the vaccine among the vaccinated infants. The sample was taken by capillary puncture from 109 infants between 3 and 6 months before vaccination, at 31.4±2 days after the first dose and at 32.3± days after the second one. The concentrations of immunoglobulin G against each immunogen of the vaccine were determined. The levels of prevaccination specific immunoglobulin G were elevated against meningococcus C. There was a statistically significant increase of atibodies for both immunogens after the first and second dose. It was more marked against meningococcus C in the first, and for meningococcus B in the secons one, which supports the presence of immunological memory.

Keywords : IgG [analysis]; ANTIBODIES, ANTI-IDIOTYPIC [analysis]; ANTIBODY FORMATION; NEISSERIA MENINGITIDIS [immunology]; BACTERIAL VACCINES [immunology]; POLYSACHARIDES, BACTERIAL OUTER MEMBRANE PRO TEINS [immunology]; ENZYME-LINKED IMMUNOSORBENT ASSAY.