Abstract

QUIRANTES HERNANDEZ, Alberto; LOPEZ GRANJA, Leonel  and  GIL SOSA, Alipio. Papel de la insulina en el tratamiento de la diabetes mellitus tipo II. Rev Cubana Med Gen Integr [online]. 1997, vol.13, n.5, pp. 482-488. ISSN 1561-3038.

The clinical, epidemiological and social characteristics of diabetes mellitus type II (DMTII) are reviewed. The physiopathology of this disease as well as its therapeutic management are analyzed. The mechanisms of action of sulphonylureas are also exposed. An explanation is given about the behavior that has been clasically followed when it is detected a secondary failure to the action of this drug, which is substituted, administrating slow insulin instead. It has been recently stated that in these cases when the administration of sulphonylurea is maintained, it is attained an adequate metabolic control by adding a small daily dosage of slow insulin, which is very advantageous for the patient. It is proposed a single therapeutic scheme with the association of both drugs, and it is suggested to male new investigations on this regards.

Keywords : DIABETES MELLITUS, NON-INSULIN-DEPENDIENT [drug therapy]; DIABETES MELLITUS, NON-INSULIN-DEPENDENT [physiopathology]; INSULIN [therapeutic use]; HYPOGLYCEMIC AGENTS [therapeutic use]; ALYBURIDE [therapeutic use]; DRUG THERAPY, COMBINATION.