Abstract

HERNANDEZ-YERO, Arturo  and  GONZALEZ, Raquel Jorge. Agentes farmacológicos actuales en el tratamiento de la diabetes mellitus no insulinodependiente. Rev Cubana Med Gen Integr [online]. 1997, vol.13, n.6, pp. 596-609. ISSN 1561-3038.

It is stated that due to the pathogenic heterogeneity of non insulin-dependent diabetes mellitus, it should be considered that different pharmacological agents will be necessary to treat this disease successfully. To this end, a bibliographical review of the present and prospective treatment lines for this complex disease is made. The current therapeutic modalities include 5 groups of esential agents: the inhibitors of the intestinal alphaglucosidases, the sulphonylureas, the biguanides, insulin, and the newly incorporated group of thiazolidinediones, whose used at the beginning of the disease or in insulin-resistant patients may delay or prevent the development of the disease, and may interfere in the progressive reduction of the pancreatic function. An important group of pharmacological agents, as well as their possible mechanisms of action, which have been investigated, are shown to widen and increase the therapeutics of diabetes. The insuline analogs, the insulinomimetic agents, and the oral insuline preparations, the non-sulphonylurea insulinotropic agents, the amylene analogs, the peptides similar to glucagon, the adrenergic alpha-2 antagonist, the modulators of glucose metabolism, and some substances of vegetal origin with possible hypoglycaemic effects, are among these agents

Keywords : NON-INSULIN-DEPENDENT DIABETES MELLITUS [therapy]; NON-INSULIN-DEPENDENT DIABETES MELLITUS [physiopathology]; NON-INSULIN-DEPENDENT DIABETES MELLITUS [metabolism]; NON-INSULIN-DEPENDENT DIABETES MELLITUS [drug effects]; GLUCOSIDASES [pharmacology]; BIGUADINES [pharmacology]; ALPHA-GLUCOSIDASES [inhibitors]; ALPHA-GLUCOSIDASES [pharmacology]; THIAZOLES [pharmacology]; SULPHONYLUREA COMPOUNDS [pharmacology]; INSULIN [therapy].