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Revista Cubana de Medicina General Integral

Print version ISSN 0864-2125On-line version ISSN 1561-3038


LUGONES BOTELL, Miguel  and  NAVARRO DESPAIGNE, Daysi A.. Lipoprotein a, atherosclerosis and replacement hormone therapy. Rev Cubana Med Gen Integr [online]. 2005, vol.21, n.3-4. ISSN 0864-2125.

A review of plasmatic lipoprotein, Lp(a), whose physiological role is little known, was made. An association between the augmented concentrations of Lp(a) and the atherosclerotic proccess has been described. Besides, its excess may lead to a reduction of the fibrinolytic activity and, therefore, favor thrombosis. The replacement hormone therapy was also analyzed. In relation to its positive effects, it improves the climacteric symptoms and prevents osteoporosis. Among its adverse effects, it has been observed a mild increase of the risk for venous thromboembolism and, more recently, in the aleady known Women's Health Initiative Study, it was reported a higher incidence of cardiovascular events for the combined therapy with equine conjugated estrogens and medroxiprogesterone, and of stroke for the estrogenic therapy. These studies put in their place the effects of this therapy that is not totally innocuous.  . Wider studies are necessary to determine the role of replacement hormone therapy and other therapeutic measures on the hemostatic system, lipid metabolism and cardiovascular disease.

Keywords : Lipoprotein a; replacement hormone therapy; hormones.

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